Biological Networks

Interaction Dynamics of Human Sirt Proteins

Dynamicity of Interactions Human SIRT-1 proteins

Recently Published article on SIRT- 1 interaction providing insights on large number of the Interactions exhibited by Sirt-1 proteins which is found to be associated with longetivity and Ageing process in C elegans , mice and budding yeast. The interaction dataset experimentally determined Interactions from various techniques. Visualization of network is carried out by Cytoscape and Spring embbeded Layout . In the article it has been stated about the second order network being scale free and small world with very high number of second order interactions. It would be interesting to have larger perspective of interactions at second order

Someof the Excerpts of GO studies of Sirt-1 proteins from the article is listed down

GO studies on the hub proteins inferred from our analysis suggest that they are involved in important biological processes related to gene regulation, Metabolism and proton co-transport
(Table 2S). In details, SLC25A3 is responsible for the inorganic phosphate transport into the mitochondrial matrix, either by proton co-transport or in exchange for hydroxyl ions [k, Entrez Gene description], while JUN interacts directly with specific target DNA sequences to regulate gene expression. The centrality analysis based on hub proteins showed SLC25A3, JUN, Sirt-1, RUVBL2 and MCF2L2 as important proteins of the network. Other Methods based on MCC, DMNC, MNC and EPC evidenced the same proteins as hub nodes along with EP300, YBX1, RPL38, AR and Sirt-2.
Genes associated with proteins and found significant in the interactome were analyzed by the BiNGO package in CytoScape. Sirt1 1st order interacting partners are involved into numerous biological processes. Sirt1 interactome is significantly involved Metabolism modulation related processes [Figure 4]. Sirt-2 in chromatin silencing at rDNA, RPS27L and RTN4 in regulating anti-apoptotic phenomena.
Certain processes, like chromatin remodeling and modification, involve many important proteins of the network like KAT2B, NCOR1, HDAC6, RRP8, HDAC2 and KAT2A. Moreover, TP53, Sirt-2, PPARGC1, CPS1 and JUN are responsible for the processes related to the response to starvation whereas the response to stress is regulated by NCOR1, MYOD1, KRT1, SIRT2, HDAC2, RPS3, RELA, FOXO1, HDAC6 and other proteins involved in ncRNA metabolic processes and in negative regulation of signaling pathways. In particular, the important processes like DNA binding activity transcription factor regulation and DNA repair are shown to have an involvement with proteins like Sirt-1, Sirt-2, TP53, PPARGC1A, JUN, EP300, HDAC2, HDAC6, KAT2A, Kat 2B, RELA, RB1, WRN, XRCC5 and XRCC6 (Figure 3S).
In particular, the sirtuin network shows that Sirt-2, HDAC6, HDAC2, Sirt-1, PPARGc1A, TRRAP are implicated in histone modification and histone deacetylation whereas SUV39H1 and DICER1 are involved in gene silencing phenomenon. The proteins in Sirt 1 interaction maps showed also different cellular localization and molecular function (Figure 4 and Table 4S). In details, Sirt family, ARNTL, WRN, EP300, SYNCRIP, JUN, RPS3 are proteins showing pleiotropicity in biological as well as in the cellular localization in the GO analysis maps. In fact, Sirt-1 interacts with cytoplasmic, nuclear, extracellular and mitochondrial proteins as found with a significant p value i.e. p; 0.0000005 that measures the statistical significance of the different essentialities of proteins implicated in the biological processes. RELA and JUN show interactions with mitochondrial proteins, Sirt-1 interacts with other cellular proteins in activating DNA repair and stress protection mechanisms.

Second order interaction of Sirt-1
The Sirt-1 second-degree interaction map is composed of 4691 nodes. These nodes correspond to different partners interacting by 221595 edges (Interactions). The second order network of Sirt-1 is scale free and small world network interacting with numerous proteins implicated in transcription and metabolism related processes. Sirt 1 has a high degree of interactions in second order interaction maps as it is having interactions with high number of proteins like PARP1 (inhibits Sirt activity) and NAMPT (regulates NAD+ levels) [Yang et al., 2006]. Analyzing centrality statistics and pattern of rearrangement of interacting nodes in Second order interactome of Sirt-1 will provide further insights on the variability in functionality, cellular localization and pleiotropicity nature of the SIRT interaction map.

“Happy SirTuinG”

Full Article can be accessed at :

Sharma A, Gautam VK, Costantini S, Paladino A and Colonna G (2012). Interactomic and pharmacological insights on human Sirt-1. Front. Pharmacol. 3:40. doi: 10.3389/fphar.2012.00040

Diseases related to Cytokine Receptors

In alphabetical order

Absent corneal

Acute cardiac allograft rejection

Acute lymphoblastic leukemia

Acute myeloid leukemia

AIDS

Allergic diseases

Allergic inflammatory diseases

Allergic pathology

Allergic rhinitis

Allergic skin disorders

Alzheimer’s disease

Angiogenesis

Anhidrosis

Antley-Bixler syndrome (ABS)

Apert syndrome (APRS)

Arthritis

Asthma

Atherosclerosis

Autoimmune diseases

autoimmune skin diseases

Beare-Stevenson cutis gyrata syndrome (BSCGS)

Bladder cancer

Bone marrow disorders

Bowing of the lower limbs

Cancer

Cancer metastasis

Cancer progression

Cardiovascular disease

Carotid Intimal medial thickness

CATSHL syndrome

Celiac disease

Cervical cancer

Chronic inflammatory diseases

Chronic myelomonocytic leukemia (CMML)

Chronic rhinosinusitis

Chronic viral infections

Congenital amegakaryocytic thrombocytopenia (CAMT)

Congenital insensitivity to pain

Conjunctival itching.

Crouzon syndrome

Cutaneous T-cell lymphoma

Diabetes

Diabetes mellitus insulin-dependent type 22 (IDDM22)

Diabetic retinopathy

Endocrine disorders

Epstein-Barr virus infection

Erythroleukemia

Excessive Nasal secretion

Familial erythrocytosis.

Familial partial lipodystrophies

Familial scaphocephaly syndrome (FSPC)

Fibrosis.

Glioma type 1 Atherosclerosis

HBV induced hepatitis

HBV induced hepatitis

HCV-induced hepatitis

Heart disease

hemangioma capillary infantile

Hematological diseases

Hepatitis

Hepatocellular carcinoma

Hepatosplenomegaly

hereditary papillary renal carcinoma (HPRC)

HIV

HIV1 Infection

Hodgkin’s disease

Human gliomas

Hypercytokinemia

hyper-IgM immunodeficiency syndrome type 3 (HIGM3)

Hyperproliferative skin diseases

Hyperproliferative skin diseases

Hypertension

Hypochondroplasia (HCH)

Idiopathic hypogonadotropic hypogonadism (IHH)

Immune

Inflammatory  Skin diseases

Inflammatory bowel disease type 17 (IBD17)

Inflammatory bowel diseases

Inflammatory diseases

Inflammatory infections

insulin resistance

Invasion

IRAN type A

Jackson-Weiss syndrome (JWS)

Japanese cedar pollinosis

Juvenile hemangioma

Kallmann syndrome type 2 (KAL2)

Keratinocytic non-epidermolytic nevus

Keratosis seborrheic (KERSEB)

Lacrimo-auriculo-dento-digital syndrome (LADDS)

Leprechaunism

Leukemia

Lung cancer

Lymphadenopathy

lymphedema hereditary type 1A (LMPH1A)

Lympho proliferative syndrome type 1A (ALPS1A)

Lymphoma

malignant melanoma

medulloblastoma

Melanoma

Mendelian susceptibility to mycobacterial disease (MSMD)

Mendenhall syndrome

Mental retardation

Metabolic diseases

Metabolic disorders

Metabolic syndrome

Metastasis

Microphthalmia syndromic type 9

Mood disorders

Muenke syndrome

Multiple Myeloma

Multiple sclerosis

Multiple sclerosis type 3 (MS3)

Myalgia

Myeloid malignancy

myeloproliferative disorder chronic with eosinophilia (MPE)

Nasal congestion

Neoplasm

Nephrotoxic Nephritis

Neuroblastomas

Neurodegenerative disorders

Neurodegenerative Disorders

Neuromuscular diseases

Non insulin-dependent diabetes mellitus (NIDDM)

Non-syndromic trigonocephaly

Obesity

Osteoglophonic dysplasia (OGD)

Osteopetrosis autosomal recessive type 2 (OPTB2)

osteoporosis and Rheumatoid Arthritis

Patellar reflexes

Pathological states related to neural cell death.

Pathology of Atopy

Pfeiffer syndrome (PS)

Progressive scoliosis

Prostate carcinoma

Psoriasis

Psoriasis type 7 (PSORS7)

Pulmonary fibrosis

Pulmonary hypoplasia or aplasia

Pulmonary surfactant metabolism dysfunction type 4 (SMDP4)

Rheumatoid Arthritis

Rheumatoid Arthritis

Self-mutilating behavior

Serositis

Severe combined immunodeficiency (SCID)

severe congenital neutropenia (SCN)

Sneezing

Spontaneous fractures

Stueve-Wiedemann syndrome

Systemic Autoimmune disease

Systemic lupus Erythematosus

systemic lupus erythematosus

Temperature instability

Th1-associated granulomatous diseases

Thanatophoric dysplasia type

Tumor

Tumor angiogenesis

Tumor growth

Tumor Metastasasis

Tumor metastasis

Tumorigenesis

Tumors

Type 2 diabetes

Type M4 acute myeloblastic leukemia

Ulcerative colitis

Uveitis

Viral diseases

Viral infections

Visceral heterotaxy autosomal type 4 (HTX4)

WHIM syndrome

Ligands of Cytokine receptor

List of Ligands (Alphabetical order)

BCA-1(BLC)

Brain Derived Neurotrophic Factor (BDNF)

cardiotrophin-1

IL29

MCP3

4-1BBL

abc

Adiponectin

Annexin II

CCL1 (SCYA1)

CCL11

CCL17

CCL19,CCL21

CCL20 (LARC)

CCL20 (LARC)

CCL22

CCL25 (SCYA25)

CCL26

CCL27

CCL27

CCL28

CD27L (CD70L)

CD30L

CD40L

Chemerin

Ciliary neurotrophic factor

CXCL1

CXCL10

CXCL11,

CXCL12

CXCL12

CXCL13,

CXCL16

CXCL2

CXCL3

CXCL3

CXCL4

CXCL5

CXCL6

CXCL6,

CXCL7

CXCL8

CXCL8

CXCL9

EGF,

eotaxin2

Epo

FGF acidic,

FGF basic

Flt3

G-CSF

Ghrelin

GM-CSF

GM-CSF

HGF

HGFL

hippocampus cells

IFNalpha

IFNbeta

IFNgamma

IL11

IL12

IL12

IL13

IL13

IL13

IL16

IL17

IL17

IL17,

IL18

IL1A

IL1B

IL1RA

IL2

IL2

IL21

IL22

IL23

IL27

IL28

IL28,

IL3

IL3,

IL31

IL-34

IL4

IL4

IL4,

IL5

IL5

IL6

IL6

IL-6

IL7

IL7

IL8

IL8

IL8

IL9

IRS-1

IRS-2

IRS-3

IRS-4

Leptin

LIF

LIGHT

Ly-6E/A

lymphotoxin A

MCP1

MCP2

MCP-2

MCP3,

MCP4

M-CSF

M-CSF

MIF

MIF

MIP1 alpha,

MIP1 beta

MPIF1

Myostatin

Nerve Growth Factor (NGF)

Neurons

Neurotrophin1

Neurotrophin3

Neurotrophin-3 (NT-3)

Neurotrophin-4 (NT-4)

Oncostatin M

OX40L

PAI-1

PAI-2

PDGF(PDGF-A;PDGF-B; PDGF-C;PDGF-D)

PDGF(PDGF-A;PDGF-B;PDGF-C;PDGF-D)

PGF

RANK-L

RANTES

RANTES

RANTES

RBP4

Resistin

TGF-alpha

TGF-beta

TNF Alpha

TNF Alpha

TNFSF18/GITRL

tPA

TPO

TRAIL:CD253

TSLP

TWEAK

uPAR

VEGF

View

vitronectin

Cytokine Receptors

Chemokine

  CCR1
  CCR10 (C-C chemokine receptor type 10)
  CCR2
  CCR3
  CCR4
  CCR5
  CCR6
  CCR7
  CCR8
  CCR9
  CXCR1
  CXCR2
  CXCR3
  CXCR4
  CXCR5
  CXCR6
  CXCR7
  IL2Rb (Interleukin-2 receptor subunit beta)
  IL5R alpha (Interleukin-5 receptor subunit alpha)

Interleukin

  CD4 (T-cell surface glycoprotein CD4)
  IL11RA (Interleukin-11 receptor subunit alpha)
  IL12RB1 (Interleukin-12 receptor subunit beta-1)
  IL12RB2 (Interleukin-12 receptor subunit beta-2)
  IL17RA (Interleukin-17 receptor A)
  IL17RB (IL-17 receptor B)
  IL17RC (Interleukin-17 receptor C)
  IL18R1 (Interleukin-18 receptor 1)
  IL1R1(Interleukin-1 receptor type 1)
  IL1R2 (Interleukin-1 receptor type 2)
  IL21R
  IL22R
  IL23R
  IL27RA
  IL28R
  IL2R Alpha (Interleukin-2 receptor subunit alpha)
  IL31RA (Interleukin-31 receptor subunit alpha)
  IL3R Alpha (Interleukin-3 receptor subunit alpha)
  IL3RB (Cytokine receptor common subunit beta)
  IL4R (Interleukin 4 receptor)
  IL4RA
  IL6RA (Interleukin-6 receptor subunit alpha)
  IL6RB (Interleukin-6 receptor subunit beta)
  IL7R Alpha (Interleukin-7 receptor subunit alpha)
  IL8RA (IL-8 receptor type 1)
  IL8RB (Interleukin 8 receptor, beta)
  IL9R ( Interleukin-9 receptor )
  Interleukin 13 receptor subunit alpha 1
  Interleukin 13 receptor subunit alpha 2
  LY6E (Lymphocyte antigen 6E)

Colony StimulatingFactor Receptor

 
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  EpoR (Erythropoietin receptor)
  G-CSF R
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  Proto-oncogene c-Mpl,Thrombopoietin receptor,
  TSLP-R (Thymic stromal lymphopoietin protein receptor)

Interferon

  IFN-lambdaR1
  IFNR-1 (Interferon alpha/beta receptor 1)
  IFNR-2 (IFN-alpha/beta receptor 2)

Tumor Necrosis Factor

  Activin receptor type-2B
  CD137 (4-1BB ligand receptor)
  CD27
  CD30
  CD40L receptor (B-cell surface antigen CD40)
  EGFR (ERB-B1)
  FASLG receptor Fas ligand;CD95
  FGFR1,Basic fibroblast growth factor receptor 1
  FGFR2,CD332
  FGFR3
  FGFR4
  FLT3 (Fms-like tyrosine kinase 3)
  GITR (Glucocorticoid-induced TNFR-related protein)
  HGFR (Hepatocyte growth factor receptor)
  LIFR
  LTAR
  Lymphotoxin-beta receptor
  MST1R (Macrophage-stimulating protein receptor)
  NGFR, Gp80-LNGFR
  NTRK1
  OX40L Receptor
  PDGFR Alpha (Alpha-type platelet-derived growth factor receptor)
  PDGFR beta (Beta-type platelet-derived growth factor receptor)
  TGF-R
  TNF-R2
  TRAIL-R1
  TRANCE (TNF-related activation-induced cytokine)
  TrkB,BDNF/NT-3 growth factors receptor
  TrkC,NTRK3
  Tweak Receptor, FGF-inducible 14
  VEGFR 1
  VEGFR 2
  VEGFR 3,FLT-4

Adipokine

  ADIPOR1
  ADIPOR2
  Annexin A11 receptor
  CD126,IL6RA
  CD130,IL6RB
  CMKLR1
  GHSR
  Insulin receptor, CD220
  LEP-R (Leptin receptor)
  PPARG (Peroxisome proliferator-activated receptor gamma)
  STRA6 (Stimulated by retinoic acid gene 6 protein homolog)
  TNFR1
  uPAR,CD87

MIF

 
  MIF-R
Chemokine
  CCR1
  CCR10 (C-C chemokine receptor type 10)
  CCR2
  CCR3
  CCR4
  CCR5
  CCR6
  CCR7
  CCR8
  CCR9
  CXCR1
  CXCR2
  CXCR3
  CXCR4
  CXCR5
  CXCR6
  CXCR7
  IL2Rb (Interleukin-2 receptor subunit beta)
  IL5R alpha (Interleukin-5 receptor subunit alpha)
Interleukin
  CD4 (T-cell surface glycoprotein CD4)
  IL11RA (Interleukin-11 receptor subunit alpha)
  IL12RB1 (Interleukin-12 receptor subunit beta-1)
  IL12RB2 (Interleukin-12 receptor subunit beta-2)
  IL17RA (Interleukin-17 receptor A)
  IL17RB (IL-17 receptor B)
  IL17RC (Interleukin-17 receptor C)
  IL18R1 (Interleukin-18 receptor 1)
  IL1R1(Interleukin-1 receptor type 1)
  IL1R2 (Interleukin-1 receptor type 2)
  IL21R
  IL22R
  IL23R
  IL27RA
  IL28R
  IL2R Alpha (Interleukin-2 receptor subunit alpha)
  IL31RA (Interleukin-31 receptor subunit alpha)
  IL3R Alpha (Interleukin-3 receptor subunit alpha)
  IL3RB (Cytokine receptor common subunit beta)
  IL4R (Interleukin 4 receptor)
  IL4RA
  IL6RA (Interleukin-6 receptor subunit alpha)
  IL6RB (Interleukin-6 receptor subunit beta)
  IL7R Alpha (Interleukin-7 receptor subunit alpha)
  IL8RA (IL-8 receptor type 1)
  IL8RB (Interleukin 8 receptor, beta)
  IL9R ( Interleukin-9 receptor )
  Interleukin 13 receptor subunit alpha 1
  Interleukin 13 receptor subunit alpha 2
  LY6E (Lymphocyte antigen 6E)
CSFR  
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  EpoR (Erythropoietin receptor)
  G-CSF R
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  Proto-oncogene c-Mpl,Thrombopoietin receptor,
  TSLP-R (Thymic stromal lymphopoietin protein receptor)
Interferon
  IFN-lambdaR1
  IFNR-1 (Interferon alpha/beta receptor 1)
  IFNR-2 (IFN-alpha/beta receptor 2)
tumor necrosis
  Activin receptor type-2B
  CD137 (4-1BB ligand receptor)
  CD27
  CD30
  CD40L receptor (B-cell surface antigen CD40)
  EGFR (ERB-B1)
  FASLG receptor Fas ligand;CD95
  FGFR1,Basic fibroblast growth factor receptor 1
  FGFR2,CD332
  FGFR3
  FGFR4
  FLT3 (Fms-like tyrosine kinase 3)
  GITR (Glucocorticoid-induced TNFR-related protein)
  HGFR (Hepatocyte growth factor receptor)
  LIFR
  LTAR
  Lymphotoxin-beta receptor
  MST1R (Macrophage-stimulating protein receptor)
  NGFR, Gp80-LNGFR
  NTRK1
  OX40L Receptor
  PDGFR Alpha (Alpha-type platelet-derived growth factor receptor)
  PDGFR beta (Beta-type platelet-derived growth factor receptor)
  TGF-R
  TNF-R2
  TRAIL-R1
  TRANCE (TNF-related activation-induced cytokine)
  TrkB,BDNF/NT-3 growth factors receptor
  TrkC,NTRK3
  Tweak Receptor, FGF-inducible 14
  VEGFR 1
  VEGFR 2
  VEGFR 3,FLT-4
adipokine
  ADIPOR1
  ADIPOR2
  Annexin A11 receptor
  CD126,IL6RA
  CD130,IL6RB
  CMKLR1
  GHSR
  Insulin receptor, CD220
  LEP-R (Leptin receptor)
  PPARG (Peroxisome proliferator-activated receptor gamma)
  STRA6 (Stimulated by retinoic acid gene 6 protein homolog)
  TNFR1
  uPAR,CD87
MIF  
  MIF-R
Chemokine
  CCR1
  CCR10 (C-C chemokine receptor type 10)
  CCR2
  CCR3
  CCR4
  CCR5
  CCR6
  CCR7
  CCR8
  CCR9
  CXCR1
  CXCR2
  CXCR3
  CXCR4
  CXCR5
  CXCR6
  CXCR7
  IL2Rb (Interleukin-2 receptor subunit beta)
  IL5R alpha (Interleukin-5 receptor subunit alpha)
Interleukin
  CD4 (T-cell surface glycoprotein CD4)
  IL11RA (Interleukin-11 receptor subunit alpha)
  IL12RB1 (Interleukin-12 receptor subunit beta-1)
  IL12RB2 (Interleukin-12 receptor subunit beta-2)
  IL17RA (Interleukin-17 receptor A)
  IL17RB (IL-17 receptor B)
  IL17RC (Interleukin-17 receptor C)
  IL18R1 (Interleukin-18 receptor 1)
  IL1R1(Interleukin-1 receptor type 1)
  IL1R2 (Interleukin-1 receptor type 2)
  IL21R
  IL22R
  IL23R
  IL27RA
  IL28R
  IL2R Alpha (Interleukin-2 receptor subunit alpha)
  IL31RA (Interleukin-31 receptor subunit alpha)
  IL3R Alpha (Interleukin-3 receptor subunit alpha)
  IL3RB (Cytokine receptor common subunit beta)
  IL4R (Interleukin 4 receptor)
  IL4RA
  IL6RA (Interleukin-6 receptor subunit alpha)
  IL6RB (Interleukin-6 receptor subunit beta)
  IL7R Alpha (Interleukin-7 receptor subunit alpha)
  IL8RA (IL-8 receptor type 1)
  IL8RB (Interleukin 8 receptor, beta)
  IL9R ( Interleukin-9 receptor )
  Interleukin 13 receptor subunit alpha 1
  Interleukin 13 receptor subunit alpha 2
  LY6E (Lymphocyte antigen 6E)
CSFR  
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  EpoR (Erythropoietin receptor)
  G-CSF R
  GM-CSFR, CD116
  M-CSFR (CSF1R)
  Proto-oncogene c-Mpl,Thrombopoietin receptor,
  TSLP-R (Thymic stromal lymphopoietin protein receptor)
Interferon
  IFN-lambdaR1
  IFNR-1 (Interferon alpha/beta receptor 1)
  IFNR-2 (IFN-alpha/beta receptor 2)
tumor necrosis
  Activin receptor type-2B
  CD137 (4-1BB ligand receptor)
  CD27
  CD30
  CD40L receptor (B-cell surface antigen CD40)
  EGFR (ERB-B1)
  FASLG receptor Fas ligand;CD95
  FGFR1,Basic fibroblast growth factor receptor 1
  FGFR2,CD332
  FGFR3
  FGFR4
  FLT3 (Fms-like tyrosine kinase 3)
  GITR (Glucocorticoid-induced TNFR-related protein)
  HGFR (Hepatocyte growth factor receptor)
  LIFR
  LTAR
  Lymphotoxin-beta receptor
  MST1R (Macrophage-stimulating protein receptor)
  NGFR, Gp80-LNGFR
  NTRK1
  OX40L Receptor
  PDGFR Alpha (Alpha-type platelet-derived growth factor receptor)
  PDGFR beta (Beta-type platelet-derived growth factor receptor)
  TGF-R
  TNF-R2
  TRAIL-R1
  TRANCE (TNF-related activation-induced cytokine)
  TrkB,BDNF/NT-3 growth factors receptor
  TrkC,NTRK3
  Tweak Receptor, FGF-inducible 14
  VEGFR 1
  VEGFR 2
  VEGFR 3,FLT-4
adipokine
  ADIPOR1
  ADIPOR2
  Annexin A11 receptor
  CD126,IL6RA
  CD130,IL6RB
  CMKLR1
  GHSR
  Insulin receptor, CD220
  LEP-R (Leptin receptor)
  PPARG (Peroxisome proliferator-activated receptor gamma)
  STRA6 (Stimulated by retinoic acid gene 6 protein homolog)
  TNFR1
  uPAR,CD87
MIF  
  MIF-R

CYTOKINE Databases

Some CYTOKINE RELATED DATABASES

 

 

 

 

CYTOKINE RECEPTOR

The main objective of CytReD (Cytokine Receptor Database) is to provide an user-friendly access for a quick review of the cytokine receptors, of their ligands, of their involvement in diseases and of their use in clinical treatments.In particular, CytReD can be used by researchers as well as physicians and clinicians to identify what cytokines are reported in the literature as significant in a given disease and in its clinical treatment.

CytReD is part of a broader project aimed to develop tools and portals able to be useful supports for a reliable predictive medicine. In fact, CytReD is also correlated with Clinical Data Mining Software (CDMS) that was recently developed in our research group to collect cytokine profiles evaluated both on healthy subjects and on patients by multiplex immunoassays and annotated with their clinical and laboratory story.

The user can search in CytReD by selecting “Cytokine Receptor Name”, “Ligands”, “Cytokine Family” or “Disease”:

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